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M5 and M6 Cytokeratin 18 Monoclonal Antibodies (K18) Research Use Only Cat. No. #10600-10650
M5 and M6 Cytokeratin 18 Monoclonal Antibodies (K18) Research Use Only Cat. No. #10600-10650
M5 and M6 Cytokeratin 18 Monoclonal Antibodies (K18) Research Use Only Cat. No. #10600-10650
M5 and M6 Cytokeratin 18 Monoclonal Antibodies (K18) Research Use Only Cat. No. #10600-10650

M5 and M6 Cytokeratin 18 Monoclonal Antibodies (K18) Research Use Only Cat. No. #10600-10650

The keratins are conserved phylogenetically and are closely related. Keratins 1-8 constitute the type II group, while keratins 9-20 constitute the type I group. Keratins provide useful markers for epithelial malignancies, distinctly reflecting ongoing cellular turnover. Certain keratins are substrates for lethal caspase activation and therefore define protein fragments during cell death.
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M5 / M6 Keratin 18 (Cytokeratin 18) monoclonal antibodies (FFPE-grade) (Prod. No. 10600-10650)

In eukaryotic cells, the cytoskeleton is composed of three different types of morphologically distinct filamentous structures:

  • microfilaments,
  • intermediate filaments (IF)
  • microtubules.

The epithelial keratins (IF types I and II, also called cytokeratins) are conserved phylogenetically and are closely related, biochemically and immunologically. Keratins 1-8 constitute the type II group (53-68 kDa, neutral to basic protein components), while keratins 9-20 constitute the type I group (40-56 kDa, acidic proteins).

Upon release from dying cells, keratins provide useful markers for epithelial malignancies, distinctly reflecting ongoing cellular turnover. Certain keratins, the most prominent example being keratin 18, are substrates for lethal caspase activation and the subsequent release of defined protein fragments occurs during apoptotic cell death.

The clinical value of determining different soluble keratin protein fragments in blood samples (i.e. using the M30 Apoptosense® ELISA or M65® ELISA) lies in the rapid and non-invasive assessment of drug efficacy or response to therapy in epithelial cell carcinomas.
 

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Instructions of Use (CE-IVD)
Manuals (RUO)
Material Safety Data Sheets
Brand PEVIVA
Code 10600

Instructions of Use (CE-IVD)

 M30 Apoptosense® ELISA
 M65® ELISA
 M65 EpiDeath® ELISA
 M65 EpiRatTM ELISA

Manuals (RUO)

 M30 CytoDeath™ ELISA

Material Safety Data Sheets

 M30 Apoptosense ELISA MSDS
 M65® ELISA MSDS
 M65 EpiDeath® ELISA MSDS
 M30 CytoDeath™ ELISA MSDS

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