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M65 EpiDeath® ELISA Cat. No. #10040
M65 EpiDeath® ELISA Cat. No. #10040

M65 EpiDeath® ELISA Cat. No. #10040

The M65 EpiDeath® ELISA is the next generation of Peviva's biomarkers and is a modified version of the M65® ELISA and is intended for the samples with high Keratin 18 plasma and serum levels (e.g. sepsis, GvHD and liver toxicity such as DILI or ALF).
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M65 EpiDeath ELISA (Prod. No. 10040)

The M65 EpiDeath ELISA is the next generation of Peviva's biomarkers. It is intended for the quantitative detection of keratin 18 (K18) present in cell culture supernatants, human serum, human plasma or other body fluids after it has been released from dying cells into the extracellular compartment. The assays offers the opportunity to quantify total cell death (due to apoptosis and necrosis) of K18 positive (epithelial) cells.

The M65 EpiDeath ELISA, when used in combination with the M30 Apoptosense ELISA (which specifically measures apoptosis), allows to distinguish different forms of epithelial cell death, especially recommended for in vitro applications (e.g. cell culture supernatants).

Where caspase-cleaved Keratin 18 (ccK18) and total Keratin levels (tK18) are compared to each other using human blood samples, published studies suggest the use of M30 Apoptosense ELISA and M65 Classic ELISA (#10020), especially where a ratio between ccK18 and tK18 is calculated.

The M65 EpiDeath ELISA is a modified version of the M65 ELISA and is intended for the samples with high Keratin 18 plasma and serum levels (e.g. sepsis, GvHD and liver toxicity such as DILI or ALF).
 

Download Product Resources
Instructions of Use (CE-IVD)
Manuals (RUO)
Material Safety Data Sheets
Brand PEVIVA
Code 10040

Instructions of Use (CE-IVD)

 M30 Apoptosense® ELISA
 M65® ELISA
 M65 EpiDeath® ELISA

Manuals (RUO)

 M30 CytoDeath™ ELISA
 M30 CytoDEATH™ MAb
 M30 CytoDEATH™ FITC MAb
 M30 CytoDEATH™ BIOTIN MAb
 M30 CytoDEATH™ Orange MAb
 M6 Keratin 18 MAb
 M5 Keratin 18 MAb

Material Safety Data Sheets

 M30 Apoptosense ELISA MSDS
 M65® ELISA MSDS
 M65 EpiDeath® ELISA MSDS
 M30 CytoDeath™ ELISA MSDS
 M30 CytoDEATH™ MAb MSDS
 M30 CytoDEATH™ FITC MAb MSDS
 M30 CytoDEATH™ BIOTIN MAb MSDS
 M30 CytoDEATH™ Orange MAb MSDS
 M6 Keratin 18 MAb MSDS
M5 Keratin 18 MAb MSDS

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    The M65® ELISA is capable of measuring the amount of Keratin 18 that is released from the dying cells of many cell cultures that are from the extracellular compartment. The M65® ELISA offers the opportunity to quantify total cell death of K18 positive cells.
  • M5 and M6 Cytokeratin 18 Monoclonal Antibodies (K18) Research Use Only Cat. No. #10600-10650

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    The keratins are conserved phylogenetically and are closely related. Keratins 1-8 constitute the type II group, while keratins 9-20 constitute the type I group. Keratins provide useful markers for epithelial malignancies, distinctly reflecting ongoing cellular turnover. Certain keratins are substrates for lethal caspase activation and therefore define protein fragments during cell death.